Related Experiment Video
Updated: Aug 19, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
TAK1-inhibitors did not reduce disease burden in a Vκ*MYC model of multiple myeloma
Erling Håland1,2, Ingrid Nyhus Moen1,2,3, Esten N Vandsemb2
1CEMIR Centre of Molecular Inflammation Research, IKOM, NTNU, Trondheim, Norway.
Objective:
Multiple myeloma is a haematological malignancy characterized by proliferation of monoclonal plasma cells in the bone marrow. Development of resistance and minimal residual disease remain challenging in the treatment of multiple myeloma. Transforming growth factor-β activated kinase 1 (TAK1) has recently gained attention as a potential drug target in multiple myeloma. This study aimed at determining the in vivo effects of TAK1-inhibitors in a Vκ*MYC multiple myeloma mouse model.
Results:
We treated mice carrying Vκ*MYC multiple myeloma cells with the TAK1-inhibitors 5Z-7-oxozeaenol and NG25. There were tendencies towards increased survival for both inhibitors, but only NG25 prolonged survival significantly. However, this effect was limited, and no differences in disease burden were observed for any of the treatments. In conclusion, although TAK1-inhibitors might prolong survival somewhat, they do not prevent disease in the Vκ*MYC mouse model of multiple myeloma.
Related Concept Videos
Inhibition of Cdk Activity
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
Targeted Cancer Therapies
There are several types of targeted therapies against...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...

