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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Antifungal drug-resistance mechanisms in Candida biofilms

Jaspreet Kaur1, Clarissa J Nobile2

  • 1Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, USA.

Current Opinion in Microbiology
|November 27, 2022
PubMed

Insights

Candida biofilms present a major challenge in treating fungal infections due to their high resistance to antifungal drugs. This review explores the mechanisms behind this drug resistance in Candida biofilms.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Infections caused by Candida species are a significant global health concern, often leading to disseminated disease.
  • Limited classes of antifungal drugs are available for treating invasive fungal infections.
  • Candida biofilms exhibit significantly higher antifungal drug resistance than planktonic cells, complicating treatment.

Purpose of the Study:

  • To review current knowledge on antifungal drug-resistance mechanisms in Candida biofilms.
  • To highlight the challenges posed by biofilm-associated Candida infections.

Main Methods:

  • Review of existing literature on Candida biofilms and antifungal drug resistance.
  • Analysis of mechanisms contributing to drug tolerance in biofilm structures.

Main Results:

  • Candida biofilms possess inherent and adaptive mechanisms conferring resistance to antifungal agents.
  • These mechanisms include altered cell wall composition, efflux pump activity, and biofilm matrix production.

Conclusions:

  • Understanding these resistance mechanisms is crucial for developing effective therapeutic strategies against Candida biofilm infections.
  • Further research is needed to overcome antifungal drug resistance in clinical settings.
Keywords:
C. albicansCandidaantifungal drugsbiofilmsdrug resistance

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