Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Aerobic Exercise Mitigates Experimental Knee Osteoarthritis via Inhibition of cGAS-STING Signaling.

Microbiology and immunology·2026

Same author

Successful Preparation of Co-BTE Metal-Organic Frameworks for All-Optical Nonlinear Switching and Photonic Diode Functions.

ACS applied materials & interfaces·2026

Same author

Repeated Annual Influenza Vaccination in Older Adults Induces Comparable Seroprotection Despite Reduced Antibody Fold Rise: A 6-Month Prospective Cohort Study in China.

Vaccines·2026

Same author

Metasurface Vision Transformer: A Generic AI Model for Metasurface Inverse Design.

Nanophotonics (Berlin, Germany)·2026

Same author

Comments on "Surgical Decision Making in Incisional Blepharoplasty in Asians".

Aesthetic plastic surgery·2026

Same author

Voltage-Controlled Dual-Band Electroluminescence from In-Doped hBN/GaN Heterojunctions for Switchable UV-Visible Emission.

ACS applied materials & interfaces·2026

Same journal

Integration of electrochemical sensors in organ-on-a-chip microfluidic platforms: Advances and perspectives.

Biosensors & bioelectronics·2026

Same journal

DNN-PURE: A deep neural network approach to paper-based urea sensing.

Biosensors & bioelectronics·2026

Same journal

Rationally architected MOF-derived Co<sub>3</sub>O<sub>4</sub>@NiMn-LDH hollow heterostructure-based sensor array empowering sensitive detection and discrimination of neurological biomarkers.

Biosensors & bioelectronics·2026

Same journal

Four-in-one multifunctional CoCu-NC@AuPt nanozyme integrated M13 phage-displayed nanobody based multimodal lateral flow immunoassay for bovine lactoferrin detection.

Biosensors & bioelectronics·2026

Same journal

A novel capillary-driven dual-mode imaging flow cytometry system for malaria parasite detection and quantification.

Biosensors & bioelectronics·2026

Same journal

Liver-targeted alkaline phosphatase-activatable fluorescent probe for imaging liver fibrosis and screening anti-fibrotic natural products.

Biosensors & bioelectronics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 19, 2025

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

Light-driven upconversion fluorescence micromotors.

Yanan Zhao¹, Wanying Song¹, Jiaqi Xu¹

¹Institute of Nanophotonics, Jinan University, Guangzhou, 511443, China.

Biosensors & Bioelectronics

|November 27, 2022

Summary

This summary is machine-generated.

New upconversion fluorescence micromotors (UCFMs) use near-infrared light for safer cell imaging and drug delivery. These UCFMs can precisely target cancer cells and measure temperature, enabling advanced biomedical applications.

Keywords:

Micromotors Optical tweezers Single-cell thermometry Targeted delivery Upconversion fluorescence

More Related Videos

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells

Published on: February 9, 2012

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

Related Experiment Videos

Last Updated: Aug 19, 2025

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells

Published on: February 9, 2012

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

Area of Science:

Biomedical Engineering
Nanotechnology
Optical Physics

Background:

Light-driven micromotors offer precise control for biomedical tasks.
Current fluorescence micromotors use UV/visible light, risking cell photodamage.
There is a need for safer, non-damaging micromotor technology.

Purpose of the Study:

To develop novel upconversion fluorescence micromotors (UCFMs) for biomedical applications.
To enable precise cancer cell targeting and temperature sensing using near-infrared light.
To demonstrate UCFMs' capability for localized drug delivery.

Main Methods:

Constructed UCFMs using lanthanide-doped (NaYF4: Yb3+, Er3+) microrods.
Utilized scanning optical tweezers (SOTs) for precise micromotor manipulation.
Measured upconversion fluorescence spectra for accurate cell temperature determination.
Demonstrated optical actuation for localized delivery of microparticles and nanoparticles.

Main Results:

UCFMs were successfully driven and excited by near-infrared light, avoiding cell photodamage.
Achieved high absolute (1.71–1.74 × 10−3 K−1) and relative (0.53–0.68% K−1) temperature sensitivity.
Successfully guided UCFMs to cancer cells and actuated local flow for targeted delivery.
Integrated sensing and actuation capabilities within a single micromotor system.

Conclusions:

UCFMs offer a safer alternative to UV/visible light micromotors for biological applications.
The developed UCFMs demonstrate potential for precise biosensing and targeted drug delivery.
This technology paves the way for advanced single-cell analysis and therapeutic interventions.