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Updated: Aug 19, 2025

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Current research topics in FAPI theranostics: a bibliometric analysis.

Andor F van den Hoven1, Ruth G M Keijsers2, Marnix G E H Lam3

  • 1Department of Nuclear Medicine, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands. a.van.den.hoven@antoniusziekenhuis.nl.

European Journal of Nuclear Medicine and Molecular Imaging
|November 27, 2022
PubMed
Summary

Fibroblast activation protein inhibitor (FAPI) imaging and therapy research is rapidly growing, primarily in diagnostic applications for cancers and benign diseases. Future studies should focus on prospective designs to establish FAPI theranostics

Keywords:
Bibliometric analysisFAPI theranosticsPositron emission tomography imaging

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Area of Science:

  • Nuclear medicine and molecular imaging
  • Radiopharmaceutical development
  • Oncology and diagnostic imaging

Background:

  • Fibroblast activation protein inhibitor (FAPI) is a key target in molecular imaging and therapy.
  • FAPI-based positron emission tomography (PET) imaging and radionuclide therapy are emerging fields.
  • Bibliometric analysis provides insights into the growth and trends of FAPI research.

Purpose of the Study:

  • To conduct a comprehensive bibliometric overview of scientific publications on FAPI PET imaging and radionuclide therapy.
  • To analyze the current landscape of FAPI research, including study designs, applications, and therapeutic outcomes.
  • To identify research gaps and future directions in FAPI theranostics.

Main Methods:

  • Systematic literature search of MEDLINE-indexed publications up to May 31, 2022.
  • Creation of an online database with hierarchical topic-related tags.
  • Frequency analysis of publication characteristics, including author origin, journals, study design, imaging techniques, radiopharmaceuticals, histopathology, cancer types, and benign diseases.

Main Results:

  • 294 original studies were identified, predominantly case reports/series (71%).
  • Most studies focused on FAPI PET/CT imaging, comparing it with 2-[18F]FDG-PET/CT and histopathology.
  • FAPI imaging is applied in malignancies (68%) and benign diseases (42%), with early reports on radionuclide therapy (5%) showing acceptable toxicity and disease control.

Conclusions:

  • FAPI research is rapidly expanding from diagnostics to early-stage radionuclide therapy.
  • A shift towards prospectively designed studies in homogenous patient groups is needed.
  • This bibliometric overview provides a foundation for future research on FAPI theranostics' clinical value.