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Related Experiment Videos

Adiaspiromycosis.

J Schwarz

    Pathology Annual
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    This study details a fungal disease, previously only in animals, now increasingly reported in humans. The granulomatous lung response is typically self-limiting, though severe cases occur.

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    Area of Science:

    • Medical Mycology
    • Infectious Diseases
    • Pathology

    Background:

    • A fungal disease, historically known only in lower animals since 1942, has seen a rise in human cases.
    • Sporadic adiaspore findings in human lungs were reported starting in 1964, followed by disseminated cases.
    • The unique finding of adiaspores in the appendix lumen is noted.

    Purpose of the Study:

    • To describe the clinical and pathological features of a disseminated fungal infection.
    • To highlight the host's granulomatous response to fungal adiaspores.
    • To discuss the self-limiting nature and potential misdiagnosis of the disease.

    Main Methods:

    • Case report analysis of disseminated fungal infections.
    • Histopathological examination of granulomatous lung and appendix tissues.

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  • Review of previously published adiaspore findings.

    • Main Results:

    • Human cases of disseminated fungal infection, characterized by numerous granulomas, have been reported globally.
    • The host response involves tuberculous granulomas composed of fibroblasts, epithelioid, and giant cells.
    • Lesions lack necrosis, contributing to their non-calcifying nature and a generally self-limiting course.

    Conclusions:

    • The disease appears to be self-limiting, with symptom severity correlating to lung parenchyma involvement.
    • Increased reporting suggests previous cases may have been misdiagnosed as other fungal infections or parasitic infestations.
    • Further recognition of adiaspore morphology is crucial for accurate diagnosis.