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Association between systemic rheumatic diseases and dementia risk: A meta-analysis
Yao-Chin Wang1,2, Muh-Shi Lin3,4,5,6, Abel Po-Hao Huang7
1Department of Emergency, Min-Sheng General Hospital, Taoyuan, Taiwan.
Frontiers in Immunology
|November 28, 2022
Summary
Systemic rheumatic diseases (SRDs) like osteoarthritis, lupus, and Sjogren's syndrome increase dementia risk. Rheumatoid arthritis (RA) showed no significant association with dementia risk in this meta-analysis.
Area of Science:
- Rheumatology
- Neurology
- Epidemiology
Background:
- Systemic rheumatic diseases (SRDs) are linked to various health conditions.
- The relationship between SRDs and dementia risk requires comprehensive investigation.
Approach:
- A systematic review and meta-analysis of observational studies was conducted.
- Data from PubMed, EMBASE, Scopus, and Web of Science (2000-2021) were analyzed.
- Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects model.
Key Points:
- Osteoarthritis, systemic lupus erythematosus, and Sjogren's syndrome were associated with an elevated dementia risk (RR 1.31, 1.43, and 1.26, respectively).
- Rheumatoid arthritis (RA) did not show a significant association with increased dementia risk (RR 0.98).
- Seventeen studies encompassing over 17 million participants were included.
Conclusions:
- This meta-analysis indicates a heightened risk of dementia in individuals with certain SRDs.
- Rheumatoid arthritis appears to be an exception, with no observed increase in dementia risk.
- Further research may elucidate the specific mechanisms linking SRDs to dementia.
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