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Measles in non-human primates

Dmitriy I Dogadov1, Karen K Kyuregyan2,3, Alexandra M Goncharenko1

  • 1Research Institute of Medical Primatology of the Ministry of Education and Science of Russia, Sochi, Russia.

Journal of Medical Primatology
|November 28, 2022
PubMed

Insights

Measles outbreaks persist globally despite vaccination. Non-human primates (NHPs) are susceptible, making them crucial models for studying measles virus and testing vaccines.

Area of Science:

  • Virology
  • Primate Research
  • Vaccinology

Background:

  • Measles outbreaks continue worldwide six decades after vaccine introduction.
  • Non-human primate (NHP) species, including apes, are susceptible to measles virus.
  • Spontaneous measles outbreaks occur in captive primate populations in zoos and research centers.

Purpose of the Study:

  • To review and analyze published data on measles virus circulation in free-living and captive primates.
  • To summarize experimental findings on measles infection models in NHPs.
  • To highlight the importance of NHPs in understanding measles pathogenesis and evaluating vaccines/treatments.

Main Methods:

  • Literature review of published data.
  • Analysis of studies on measles virus in wild and captive primate populations.
  • Examination of experimental NHP infection models.

Main Results:

  • NHPs are susceptible to measles virus, with documented outbreaks in captive settings.
  • Experimental NHP models provide insights into measles virus biology and pathogenesis.
  • NHP studies are essential for vaccine and therapeutic development.

Conclusions:

  • Despite vaccination, measles remains a global concern.
  • Non-human primates are vital for measles research, offering unique insights into the virus.
  • Continued research using NHPs is indispensable for controlling measles.
Keywords:
measlesmonkeysreview

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