[Acute respiratory viral infections in monkeys]
D I Dogadov1, K K Kyuregyan2,3,4, A A Minosyan1
1Kurchatov Complex of Medical Primatology of NRC «Kurchatov Institute».
Voprosy Virusologii
|April 15, 2025
Summary
Acute respiratory viral infections (ARVI) pose significant risks to primate health, impacting both wild and captive populations. This review analyzes ARVI agents in primates and their use in disease modeling for vaccine and drug development.
Area of Science:
- Veterinary Virology
- Primate Pathology
- Infectious Disease Epidemiology
Background:
- Acute respiratory viral infections (ARVI) are a major threat to primate health, causing significant morbidity and mortality in captive and wild populations.
- These viruses can also infect humans, highlighting the zoonotic potential and importance of studying primate ARVI.
- Primates, including apes, are susceptible to a range of ARVI, with documented outbreaks in zoological and research settings.
Purpose of the Study:
- To review and synthesize existing literature on the prevalence and circulation of ARVI pathogens in diverse primate populations.
- To analyze the role of primates in ARVI pathogenesis and transmission, including zoonotic implications.
- To evaluate the utility of primate models in understanding ARVI and developing countermeasures.
Main Methods:
- Comprehensive literature search of published data on ARVI in wild and captive primates.
- Analysis of reported ARVI causative agents, including parainfluenza viruses, adenoviruses, RSV, influenza, rhinoviruses, coronaviruses, metapneumoviruses, and bocaviruses.
- Review of studies involving experimental modeling of ARVI in non-human primates.
Main Results:
- ARVI agents are widespread among various primate species, affecting both free-ranging and captive individuals.
- Documented outbreaks in zoological facilities underscore the susceptibility of primates to these pathogens.
- Primate models offer critical insights into ARVI biology, pathogenesis, and serve as platforms for therapeutic and vaccine testing.
Conclusions:
- Understanding ARVI dynamics in primates is crucial for conservation, animal welfare, and public health due to zoonotic risks.
- Primates serve as valuable models for studying ARVI, contributing to the development of effective interventions.
- Continued research on ARVI in primates is essential for managing disease outbreaks and advancing biomedical research.
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