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MICEmi: A method to identify cognitive endophenotypes of mental illnesses
Patricia Correa-Ghisays1,2,3,4, Joan Vicent Sánchez-Ortí2,3,4, Vicent Balanzá-Martínez1,3,4,5
1Center for Biomedical Research in Mental Health Network (CIBERSAM), ISCIII, Madrid, Spain.
Background:
Characterizing neurocognitive endophenotypes of mental illnesses (MIs) could be useful for identifying at-risk individuals, increasing early diagnosis, improving disease subtyping, and proposing therapeutic strategies to reduce the negative effects of the symptoms, in addition to serving as a scientific basis to unravel the physiopathology of the disease. However, a standardized algorithm to determine cognitive endophenotypes has not yet been developed. The main objective of this study was to present a method for the identification of endophenotypes in MI research.
Methods:
For this purpose, a 14-expert working group used a scoping review methodology and designed a method that includes a scoring template with five criteria and indicators, a strategy for their verification, and a decision tree.
Conclusions:
This work is ongoing since it is necessary to obtain external validation of the applicability of the method in future research.
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