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miRNA Biogenesis and Regulation of Diseases: An Updated Overview
1Department of Biophysics, University of Delhi, New Delhi, India.
Methods in Molecular Biology (Clifton, N.J.)
|November 28, 2022
Summary
MicroRNAs (miRNAs) are small molecules regulating genes. They show promise as therapeutic agents and biomarkers for diseases like cancer and neurodegeneration.
Area of Science:
- Molecular Biology
- Genetics
Background:
- MicroRNAs (miRNAs) are small RNA molecules crucial for gene silencing and translational repression.
- Found in eukaryotes and prokaryotes, miRNAs play vital roles in biological processes and disease development.
Approach:
- This chapter summarizes microRNA biogenesis.
- It explores the potential roles of miRNAs in various diseases, including neurodegenerative diseases, cardiovascular disease, and cancer.
Key Points:
- miRNAs regulate gene expression by targeting messenger RNAs (mRNAs).
- Dysregulation of miRNAs is implicated in numerous human diseases.
- miRNA-based therapies offer promising therapeutic applications.
Conclusions:
- miRNAs are essential regulators with conserved functions across species.
- They hold significant potential as diagnostic and prognostic biomarkers.
- miRNAs can predict drug response, paving the way for personalized medicine.
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