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    This study introduces interpretable machine learning models that explain decisions in user-understandable terms. The novel approach uses domain-specific queries to improve accuracy and transparency in sensitive fields like healthcare.

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    Area of Science:

    • Artificial Intelligence
    • Machine Learning
    • Explainable AI (XAI)

    Background:

    • High-performance machine learning models often lack transparency, hindering adoption in critical sectors like healthcare.
    • Interpretability is essential for building trust and enabling effective use of AI in risk-sensitive applications.
    • Current explanation methods are often post-hoc and may not align with domain-specific user needs.

    Purpose of the Study:

    • To develop machine learning algorithms that are interpretable by design.
    • To ensure explanations are expressed in domain- and task-specific language understandable to end-users.
    • To minimize the number of queries required for accurate predictions while maintaining interpretability.

    Main Methods:

    • Models are based on user-defined, task-specific binary functions of data for clear interpretation.
    • Queries are selected sequentially based on information gain to minimize prediction effort.
    • A Variational Autoencoder (VAE) and Unadjusted Langevin MCMC algorithm are used to select informative queries, handling conditional dependencies.

    Main Results:

    • The proposed method enables online determination of query chains of variable depth to resolve prediction ambiguities.
    • Experiments on computer vision and natural language processing tasks show the approach's effectiveness.
    • The method demonstrates superiority over existing post-hoc explanation techniques.

    Conclusions:

    • Interpretable machine learning by design, using domain-specific language, is crucial for sensitive applications.
    • The novel query-selection strategy enhances prediction accuracy and transparency.
    • This approach offers a more robust and user-centric alternative to post-hoc explanations in AI.