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Updated: Aug 19, 2025
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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
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Cell delivery devices for cancer immunotherapy.
Ping Wen1, Wei Wu2, Feifan Wang1
1Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Summary
Adoptive cell therapy (ACT) shows promise for cancer but struggles with solid tumors. New delivery devices aim to improve cell therapy effectiveness for solid tumors by optimizing delivery and the tumor environment.
Area of Science:
- Oncology and Immunology
- Biomedical Engineering
Background:
- Adoptive cell therapy (ACT) using immune cells offers targeted cancer treatment, with success in blood cancers.
- Significant limitations exist in eradicating solid tumors with current intravenous ACT methods.
Approach:
- This review explores innovative cell delivery strategies and devices for enhancing ACT efficacy in solid tumors.
- Focuses on improving administration routes, cell viability, and normalizing the tumor microenvironment.
Key Points:
- Novel delivery devices are crucial for overcoming barriers to ACT in solid tumors.
- Optimizing cell delivery enhances therapeutic potency and patient outcomes.
- The tumor microenvironment significantly impacts ACT success.
Conclusions:
- Advancements in cell delivery devices are essential for realizing the full potential of ACT in solid tumor treatment.
- Further research into novel delivery systems and strategies is warranted.
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