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A two-dimensional disposable full-history time-temperature indicator for cold chain logistics.
Wen Shou1, Yueliang Wang2, Yuanyuan Yao2
1Jiaxing Key Laboratory of Molecular Recognition and Sensing, College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, 314001, PR China; Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, PR China.
Analytica Chimica Acta
|November 28, 2022
Summary
New full-history time-temperature indicators (FHTTI) use multicolor plasmonic hydrogels to track temperature and time. This innovation ensures accurate cold chain monitoring for sensitive products like vaccines and foods.
Area of Science:
- Materials Science
- Chemical Engineering
- Biotechnology
Background:
- Accurate temperature monitoring is vital for the safety and efficacy of temperature-sensitive products during distribution.
- Traditional digital thermometers are costly and prone to data tampering, while existing low-cost indicators lack full time-temperature history.
- Current methods fail to provide comprehensive data on product exposure to varying temperatures throughout the supply chain.
Purpose of the Study:
- To develop a novel full-history time-temperature indicator (FHTTI) capable of providing accurate and complete temperature and time data.
- To overcome the limitations of traditional time-temperature indicators (TTIs) in cold chain logistics.
- To enable individual product monitoring within the cold chain.
Main Methods:
- Fabrication of multicolor plasmonic hydrogels capable of in-situ gold nanoparticle formation.
- Development of a two-dimensional indicator utilizing color and length to independently represent temperature and time.
- Testing the FHTTI's performance under complex variable-temperature conditions for extended durations.
Main Results:
- The developed FHTTI successfully integrates color and length as non-interfering parameters for indicating temperature and time.
- The indicator demonstrated accurate monitoring of time-temperature changes for over 30 days under dynamic temperature fluctuations.
- The FHTTI provides a complete and reliable record of the time-temperature history for individual products.
Conclusions:
- The novel FHTTI based on plasmonic hydrogels offers a significant advancement over traditional TTIs.
- This technology provides accurate, tamper-proof, and comprehensive time-temperature monitoring for cold chain logistics.
- The FHTTI holds great potential for ensuring the quality and safety of sensitive products throughout distribution.
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