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Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
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PET-Computed Tomography in Bone and Joint Infections.
Sarvesh Loharkar1, Sandip Basu1
1Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai 400 012, India; Homi Bhabha National Institute, 2nd floor, BARC Training School Complex, Anushaktinagar, Mumbai, Maharashtra 400094, India.
PET Clinics
|November 28, 2022
Summary
Positron emission tomography/computed tomography (PET/CT) offers advanced insights into bone and joint infections, evaluating disease extent and molecular activity. This imaging technique aids in assessing treatment response for conditions like osteomyelitis and prosthetic joint infections.
Area of Science:
- Nuclear Medicine
- Radiology
- Infectious Diseases
Background:
- Conventional imaging modalities have limitations in fully characterizing bone and joint infections.
- Accurate assessment of disease extent and active pathology is crucial for effective treatment.
Purpose of the Study:
- To review the clinical utility of PET/CT imaging in diagnosing and managing bone and joint infections.
- To highlight the advantages of PET/CT over traditional imaging techniques.
Main Methods:
- Review of clinical applications of fluorodeoxyglucose (FDG)-PET/CT.
- Discussion of other PET tracers (e.g., 18F-sodium fluoride, 68Ga-citrate, 18F-FDG-labeled WBCs).
- Brief mention of emerging PET/MR technology.
Main Results:
- PET/CT provides comprehensive information on disease extent, molecular activity, and treatment response.
- FDG-PET/CT is valuable in osteomyelitis, prosthetic joint infections, diabetic foot infections, and skeletal involvement in systemic diseases.
- Alternative tracers and PET/MR show promise for specific applications.
Conclusions:
- PET/CT imaging significantly enhances the evaluation of bone and joint infections.
- It offers superior diagnostic and prognostic information compared to conventional methods.
- Further research into novel tracers and hybrid imaging modalities is warranted.
Keywords:
Aseptic loosening of prosthesisDiabetic footFDGOsteomyelitisPETPET-CTPET-MRIProsthesis infectionMore Related Videos
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