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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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Related Experiment Video

Updated: Aug 19, 2025

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

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Atherosclerosis Imaging: Positron Emission Tomography.

Sze Jia Ng1, Hui Chong Lau1, Rizwan Naseer1

  • 1Department of Medicine, Crozer-Chester Medical Center, 1 Medical Center Boulevard, Upland, PA 19013, USA.

PET Clinics
|November 28, 2022
PubMed
Summary
This summary is machine-generated.

Positron emission tomography (PET) imaging offers a new way to assess atherosclerosis by detecting molecular changes. Key PET tracers like 18F-fluorodeoxyglucose and 18F-sodium fluoride visualize arterial inflammation and microcalcification.

Keywords:
Alavi-Carlsen calcification scoreCholineCoronary artery diseaseFDGGlobal assessmentNaFPET/CTPeripheral arteries disease

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Area of Science:

  • Cardiovascular Imaging
  • Molecular Imaging
  • Atherosclerosis Research

Background:

  • Traditional atherosclerosis imaging relies on anatomical changes seen in angiography and CT.
  • Molecular imaging with PET offers a new paradigm for assessing atherosclerosis.
  • 18F-fluorodeoxyglucose (FDG) PET for atherosclerotic changes was first described over 20 years ago.

Purpose of the Study:

  • To discuss the evolving roles of PET tracers in atherosclerosis imaging.
  • To highlight tracers targeting macrophage activity, neoangiogenesis, and smooth muscle activity.
  • To focus on FDG and 18F-sodium fluoride for arterial wall inflammation and microcalcification.

Main Methods:

  • Review of existing literature on PET tracers for atherosclerosis.
  • Discussion of the application of 18F-fluorodeoxyglucose (FDG) in imaging atherosclerotic plaques.
  • Exploration of novel PET tracers for molecular assessment of atherogenic changes.

Main Results:

  • PET imaging allows for the assessment of molecular changes in atherosclerosis.
  • 18F-fluorodeoxyglucose (FDG) is a key PET tracer for detecting atherosclerotic changes.
  • 18F-sodium fluoride PET can identify arterial wall microcalcification.

Conclusions:

  • PET imaging represents a significant advancement in atherosclerosis assessment.
  • FDG and 18F-sodium fluoride are leading PET tracers for visualizing arterial inflammation and microcalcification.
  • Further development of PET tracers will enhance understanding and management of atherosclerosis.