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RNA Modifications Meet Tumors

Zhiyuan Yang1,2, Siyu Zhang1,2, Tian Xia1,2

  • 1Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, People's Republic of China.

Cancer Management and Research
|November 29, 2022
PubMed

Insights

RNA modifications are crucial for gene expression and cell processes. This review details key RNA modifications like N6-methyladenine (m6A) and their roles in tumor development and therapy.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Research

Background:

  • RNA modifications regulate gene expression, RNA stability, and cell cycle.
  • These modifications are implicated in tumor development, metastasis, and drug resistance.
  • Understanding RNA modifications is key to comprehending tumor biology.

Purpose of the Study:

  • To review the diverse functions of RNA modifications in cancer.
  • To highlight the roles of specific RNA modifications in tumor microenvironments and therapies.
  • To provide insights into the therapeutic potential of targeting RNA modifications.

Main Methods:

  • Literature review of current research on RNA modifications in tumors.
  • Discussion of identified RNA modification types and their mechanisms.
  • Analysis of the impact of RNA modifications on solid and liquid tumors.

Main Results:

  • Several RNA modifications, including N6-methyladenine (m6A), 5-methylcytosine (m5C), N7-methyladenosine (m7G), N1-methyladenosine (m1A), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I), are discussed.
  • These modifications significantly influence tumor progression, microenvironment, and therapeutic responses.
  • The review consolidates current knowledge on the multifaceted roles of RNA modifications in oncology.

Conclusions:

  • RNA modifications are critical regulators in cancer biology.
  • Targeting RNA modifications offers promising therapeutic strategies for various tumors.
  • Further research into RNA modification pathways is essential for advancing cancer treatment.
Keywords:
RNA modificationnon-coding RNAtumortumor microenvironmenttumor therapy

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