Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

522
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
522
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

227
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
227
Birth Control Methods01:22

Birth Control Methods

1.4K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
1.4K
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

609
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
609
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

19
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
19
Angina IV: Management01:26

Angina IV: Management

15
IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
15

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Grower or Shower: Is It Even a Thing? Penile Growth Patterns and Erectile Dysfunction Aetiology in Growers and Showers.

Andrology·2026
Same author

Predictors of penile prosthesis length: results from the PHOENIX registry.

International journal of impotence research·2026
Same author

Impact of PA-100 AST System Rapid Antibiotic Susceptibility Test on Antibiotic Prescription for Community-Acquired Urinary Tract Infections in Spanish Primary Care Settings.

Antibiotics (Basel, Switzerland)·2026
Same author

Development and validation of PEYRO-Q: a novel multidimensional patient-reported outcome measure for Peyronie's disease.

Sexual medicine·2026
Same author

Peyronie's disease in Spain: a prospective study.

Sexual medicine·2026
Same author

Oral suspension versus tablet sildenafil for erectile dysfunction: a prospective multicenter comparative study on patient satisfaction.

International journal of impotence research·2026

Related Experiment Video

Updated: Aug 19, 2025

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
02:21

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

Published on: March 15, 2024

758

Conservative Non-surgical Options for Erectile Dysfunction.

Manuel Alonso-Isa1,2,3, Borja García-Gómez1,2,3, Ignacio González-Ginel1

  • 1Department of Urology, Hospital Universitario 12 Octubre, Instituto de Investigación Sanitaria Hospital, 12 de Octubre (imas12), Madrid, Spain.

Current Urology Reports
|November 29, 2022
PubMed
Summary
This summary is machine-generated.

This review highlights effective conservative treatments for erectile dysfunction (ED), such as new PDE5 inhibitors and therapies like shock wave treatment. Other promising ED treatments need more research for clinical recommendations.

Keywords:
Conservative treatmentErectile dysfunctionImpotenceNon-surgical treatment

More Related Videos

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.5K
Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation
03:51

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Published on: December 8, 2023

3.0K

Related Experiment Videos

Last Updated: Aug 19, 2025

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
02:21

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

Published on: March 15, 2024

758
Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.5K
Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation
03:51

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Published on: December 8, 2023

3.0K

Area of Science:

  • Urology
  • Andrology
  • Sexual Medicine

Background:

  • Erectile dysfunction (ED) is a common condition affecting men's health and quality of life.
  • Conservative non-surgical options are increasingly sought for managing ED.
  • Recent advancements offer a wider range of therapeutic choices for ED.

Purpose of the Study:

  • To conduct a narrative review of recent evidence on conservative non-surgical treatments for ED.
  • To evaluate the efficacy and evidence base for various ED therapeutic modalities.
  • To identify established treatments and areas requiring further research in ED management.

Main Methods:

  • A comprehensive literature search was performed in MEDLINE, Embase, and Cochrane databases.
  • Included studies were published in English between May 2017 and May 2022.
  • Excluded were basic research, animal studies, reviews, meta-analyses, congress reports, and clinical trial protocols without results.

Main Results:

  • Several ED treatments demonstrate good efficacy and evidence, including new phosphodiesterase type 5 (PDE5) inhibitor formulations, intracavernous injections, shock wave therapy, hormonal therapy, and psychosexual therapy.
  • Emerging therapies like stem cell therapy, platelet-rich plasma (PRP) injections, and nutraceuticals show promise but require more robust clinical trials.
  • Treatment effectiveness depends on patient-specific factors like comorbidities, ED etiology, and severity.

Conclusions:

  • Established conservative therapies like new PDE5 inhibitors and shock wave therapy are effective and safe for specific patient groups.
  • Some novel ED treatments require further randomized studies and longer follow-up before widespread clinical recommendation.
  • Personalized approaches considering patient factors are crucial for successful conservative ED management.