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Utilizing Biologics in Drug Desensitization
Barbara C Yang1,2, Mariana C Castells3
1Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Room 5002-B, Boston, MA, 02115, USA. byang@ribontx.com.
Current Allergy and Asthma Reports
|November 29, 2022
Summary
Rapid drug desensitization offers a safe method for patients hypersensitive to biologics. This review covers advancements in desensitizing to biologics and using biologics for desensitization to other medications.
Area of Science:
- Immunology
- Pharmacology
- Allergy and Clinical Immunology
Background:
- Biologics, including monoclonal antibodies and vaccines, are crucial in treating diseases but can cause hypersensitivity reactions.
- Hypersensitivity to biologics is common, necessitating strategies for continued treatment.
- Understanding biomarkers and excipient roles is key to managing these reactions.
Purpose of the Study:
- To review the latest advancements in rapid drug desensitization for biologics.
- To explore desensitization to biologics themselves.
- To examine the use of biologics in desensitizing patients to other biologic and nonbiologic drugs.
Main Methods:
- Literature review focusing on recent advancements in biologics and desensitization.
- Analysis of desensitization procedures for biologics.
- Investigation into the role of biologics in desensitizing to other medications.
Main Results:
- Standardized desensitization procedures for biologics are safe and effective.
- Biomarkers aid in identifying and classifying hypersensitivity reactions.
- Certain biologics can facilitate desensitization to other drugs, including mRNA vaccines.
Conclusions:
- Rapid drug desensitization is a viable option for patients with hypersensitivity to biologics.
- Biologics are increasingly important in managing hypersensitivity reactions and enabling continued therapy.
- Further research into biologics and desensitization protocols is warranted.
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