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Utilizing Biologics in Drug Desensitization.

Barbara C Yang^1,2, Mariana C Castells³

¹Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Room 5002-B, Boston, MA, 02115, USA. byang@ribontx.com.

Current Allergy and Asthma Reports

|November 29, 2022

Summary

Rapid drug desensitization offers a safe method for patients hypersensitive to biologics. This review covers advancements in desensitizing to biologics and using biologics for desensitization to other medications.

Keywords:

Biologics COVID-19 vaccine Desensitization Hypersensitivity Monoclonal antibodies Nanobodies

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Area of Science:

Immunology
Pharmacology
Allergy and Clinical Immunology

Background:

Biologics, including monoclonal antibodies and vaccines, are crucial in treating diseases but can cause hypersensitivity reactions.
Hypersensitivity to biologics is common, necessitating strategies for continued treatment.
Understanding biomarkers and excipient roles is key to managing these reactions.

Purpose of the Study:

To review the latest advancements in rapid drug desensitization for biologics.
To explore desensitization to biologics themselves.
To examine the use of biologics in desensitizing patients to other biologic and nonbiologic drugs.

Main Methods:

Literature review focusing on recent advancements in biologics and desensitization.
Analysis of desensitization procedures for biologics.
Investigation into the role of biologics in desensitizing to other medications.

Main Results:

Standardized desensitization procedures for biologics are safe and effective.
Biomarkers aid in identifying and classifying hypersensitivity reactions.
Certain biologics can facilitate desensitization to other drugs, including mRNA vaccines.

Conclusions:

Rapid drug desensitization is a viable option for patients with hypersensitivity to biologics.
Biologics are increasingly important in managing hypersensitivity reactions and enabling continued therapy.
Further research into biologics and desensitization protocols is warranted.