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Glucocorticoid-Induced Bone Loss: Dietary Supplementation Recommendations to Reduce the Risk for Osteoporosis and
Kristen L Chen1, Nicholas P Gannon1, Josef N Tofte1
1Drs. Chen, Tofte, and Shields are from the University of Wisconsin School of Medicine and Public Health, Madison. Drs. Chen and Shields are from the Department of Dermatology, and Dr. Tofte is from the Department of Orthopedic Surgery. Dr. Gannon is from the Department of Orthopedic Surgery, University of Minnesota, Minneapolis.
Abstract:
Glucocorticoids (GCs) are among the most widely prescribed medications in dermatologic practice. Although considered generally safe and efficacious, prolonged use and high dosing regimens may precipitate GC-induced osteoporosis, which contributes to an increased risk for fragility fractures. Dermatologists using and prescribing GCs must be aware of the risk for GC-induced osteoporosis. This review details the risks for osteoporosis and osteoporotic (OP) fractures in the setting of topical, intralesional, intramuscular, and systemic GC treatment, as well as nutritional supplementation recommendations that may reduce the risk of these adverse effects.
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