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A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents

Roxane Dumont1, Viviane Richard1, Elsa Lorthe1

  • 1Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.

Nature Communications
|November 29, 2022
PubMed

Insights

Pediatric post-COVID syndrome affects 9.1% of seropositive children, especially adolescents. Risk factors include older age, lower socioeconomic status, and chronic conditions like asthma, highlighting the need for early screening.

Area of Science:

  • Pediatric infectious diseases
  • Public health
  • Epidemiology

Background:

  • Post-COVID syndrome in children and adolescents is under-researched.
  • Understanding its prevalence and risk factors is crucial for effective management.

Purpose of the Study:

  • To investigate the prevalence and risk factors of pediatric post-COVID syndrome.
  • To stratify findings based on serological status in a population-based sample.

Main Methods:

  • Utilized data from the SEROCoV-KIDS cohort study in Geneva, Switzerland.
  • Tested 1034 children (6 months-17 years) for anti-SARS-CoV-2 antibodies.
  • Collected parent-reported data on persistent symptoms (over 12 weeks) compatible with post-COVID.

Main Results:

  • Seropositivity rate was 55.1% (570/1034).
  • Prevalence of persistent symptoms was 9.1% in seropositive children vs. 5.0% in seronegatives (adjusted prevalence difference: 4.1%).
  • Adolescents showed a higher risk (8.3%), with older age, lower socioeconomic status, and chronic conditions (especially asthma) identified as risk factors.

Conclusions:

  • A significant proportion of SARS-CoV-2-seropositive children, particularly adolescents, experience persistent post-COVID symptoms.
  • Findings underscore the need for early screening and primary care management of pediatric post-COVID.
  • Further research is warranted to fully understand and address pediatric post-COVID syndrome.

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