Related Experiment Video
Updated: Aug 19, 2025
10:39
Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
Published on: December 7, 2011
15.2K
Longitudinal Deficiency: A Case Report on Congenital Limb Deformity
Asna Tasleem1, Alana Ebbitt E Ernharth2, Elizabeth Imboden3
1Family and Community Medicine, WellSpan Good Samaritan Hospital, Lebanon, USA.
Cureus
|November 30, 2022
Summary
Congenital limb reduction defects, particularly upper limb deficiencies, impact many newborns. This case highlights a rare instance of isolated longitudinal ulnar deficiency without associated syndromes.
Area of Science:
- Medical Genetics
- Developmental Biology
- Pediatric Orthopedics
Background:
- Congenital limb reduction defects occur in approximately 1 in 1,900 US births.
- Upper limb deficiencies are the most common type, accounting for 58.5% of cases.
- Longitudinal deficiencies involve the long axis of the limb, potentially affecting single or multiple bones.
Observation:
- A newborn presented with longitudinal ulnar deficiency.
- This specific limb deficiency was present without any other commonly associated congenital syndromes.
- The case represents a unique clinical presentation.
Findings:
- The infant exhibited a congenital longitudinal ulnar deficiency.
- No other syndromic features were identified, distinguishing this case from typical presentations.
- This highlights the variability in congenital limb malformations.
Implications:
- Understanding isolated limb deficiencies is crucial for accurate diagnosis and genetic counseling.
- This case expands the known spectrum of congenital ulnar deficiency presentations.
- Further research into the etiology of isolated limb defects is warranted.
Related Concept Videos
01:09Changes in the Appendicular Skeleton with Age
2.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.2K
01:15Deformation of a Beam under Transverse Loading
402
Understanding beam deflection, particularly for indeterminate beams with overhanging segments and multiple concentrated loads, is crucial for ensuring structural integrity and functionality. The process begins with constructing an accurate free-body diagram, which helps identify the forces and moments acting on the beam. This diagram is vital for visualizing how bending moments vary along the beam's length, influencing its curvature.
The insights from the bending moment diagram extend to...
The insights from the bending moment diagram extend to...
402
01:07Development of the Limb Synovial Joints
1.5K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.5K
01:11Deformation of Member under Multiple Loadings
203
When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
203
01:17Beams with Unsymmetric Loadings
155
Analyzing a supported beam under unsymmetrical loadings is essential in structural engineering to understand how beams respond to varied force distributions. This analysis involves calculating the deflection and identifying points where the slope of the beam is zero, which are crucial for ensuring structural stability and functionality.
The first moment-area theorem determines the slope at any point on the beam. This theorem indicates that the change in slope between two points on a beam...
The first moment-area theorem determines the slope at any point on the beam. This theorem indicates that the change in slope between two points on a beam...
155