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Delayed Conversion of a Fibroadenoma Into a Large Phyllodes Tumor: A Case Report.
Thomas C Hartmann1, Mariam W Hanna2
1Radiology, University of Central Florida College of Medicine, Orlando, USA.
Cureus
|November 30, 2022
Summary
This case report details a rare instance of a fibroadenoma transforming into a phyllodes tumor over eight years. It highlights imaging findings and discusses potential genomic mechanisms behind this breast neoplasm progression.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Phyllodes tumors are rare breast neoplasms with overlapping clinical features with fibroadenomas.
- The transformation mechanism from fibroadenoma to phyllodes tumor remains poorly understood.
Observation:
- A 50-year-old female presented with a large phyllodes tumor.
- She had a history of an excised, biopsy-proven fibroadenoma eight years prior to presentation.
Findings:
- The case report presents imaging findings of the phyllodes tumor.
- Plausible mechanisms for fibroadenoma to phyllodes tumor conversion, including genomic alterations, are discussed.
Implications:
- Understanding the progression from benign fibroadenoma to malignant phyllodes tumor is crucial for diagnosis and treatment.
- Further research into the genomic underpinnings of this transformation may reveal new therapeutic targets.
