Related Experiment Video
Updated: Aug 19, 2025
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
Published on: March 12, 2018
Brain metastasis from a thoracic myxofibrosarcoma: A case report and literature review
Otávio da Cunha Ferreira Neto1, Roberto Borges Bezerra2, Rhuann Pontes Dos Santos Silva1
1Department of Medicine, Catholic University of Pernambuco, Recife, Brazil.
Background:
Myxofibrosarcoma (MFS) is a type of sarcoma that mainly affects elderly people; it represents only 5% of all sarcomas and shows no line of differentiation. Intracranial MFS is a rare condition. At present, limited data exist regarding brain metastasis from MFS. This article reports a case of MFS and reviews the literature regarding MFS metastasis.
Case Description:
We report a case of brain metastasis from chest wall MFS. The patient was diagnosed with an anterior thoracic MFS and underwent surgery and radiotherapy. One year later, he noticed a tumor on his left shoulder, and more than 1 year thereafter, bilateral lung metastasis was observed. Twelve months after lung metastasis, he presented to the emergency department and underwent contrast-enhanced magnetic resonance imaging, which demonstrated a left frontal tumor suggestive of brain metastasis. Since the main hypothesis was a sarcoma metastasis at the location close to the left motor area, and the patient had a good Karnofsky performance scale, the patient underwent neuronavigation-guided surgery. After surgery, the patient developed Grade III hemiparesis and aphasia. Brain tumor histopathology confirmed a malignant neoplasm with osteosarcomatous differentiation and metastasis from MFS.
Conclusion:
We report a rare case of MFS metastasis. To the best of our knowledge, this is the eighth case of intracerebral metastasis from MFS.
Insights
This study details a rare case of brain metastasis from chest wall myxofibrosarcoma (MFS) in an elderly patient. Intracranial MFS metastasis is uncommon, highlighting the need for awareness of MFS metastatic potential.
Area of Science:
- Oncology
- Neurosurgery
- Pathology
Background:
- Myxofibrosarcoma (MFS) is a rare soft tissue sarcoma predominantly affecting the elderly, characterized by its lack of differentiation.
- Intracranial metastasis from MFS is exceptionally rare, with limited existing literature.
- This report contributes to understanding MFS metastatic patterns, particularly to the brain.
Observation:
- A patient with chest wall MFS developed sequential metastasis to the shoulder and lungs.
- Magnetic resonance imaging revealed a left frontal brain tumor, suspected to be MFS metastasis.
- The patient underwent image-guided surgery due to a favorable Karnofsky performance scale.
Findings:
- Histopathological analysis confirmed the brain tumor as a malignant neoplasm with osteosarcomatous differentiation, representing metastasis from MFS.
- This case represents the eighth documented instance of intracerebral metastasis from MFS.
- Post-operative complications included Grade III hemiparesis and aphasia.
Implications:
- This case underscores the potential for MFS to metastasize intracranially, even after initial treatment.
- Increased vigilance and further research are warranted for managing MFS metastatic disease.
- Understanding rare metastatic patterns is crucial for improving patient outcomes in sarcoma treatment.
More Related Videos
13:41Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
Published on: January 13, 2023
08:01Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
