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Updated: Aug 19, 2025
Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
[Patient-derived tumor organoids (or tumoroid) as valuable precision medicine tools]
Marion Perréard1, Romane Florent2, Lucie Thorel1
1Normandie université, UNICAEN, Inserm U.1086 ANTICIPE, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers, Caen, France. - UNICANCER, Centre de lutte contre le cancer F. Baclesse, Caen, France.
Abstract:
Review of literature shows that it is possible to establish tumor-derived organoids, or tumoroids, from almost any type of tumor, and that these "micro-tumors" could be used to develop functional assays allowing the prediction of the patient response to treatments and/or the identification of predictive molecular signatures associated with the development of these therapies. Although it is still essential to optimize culture conditions to promote and accelerate the establishment of tumoroids, or to recapitulate tumor microenvironment, many applications are now possible in the field of prediction of response to treatments and in guiding therapeutic decision-making. Using tumoroids as standard tools in clinical oncology could make precision oncology enter a new era in the coming decade. Numerous ongoing research and clinical trials conducted throughout the world aim to validate the interest of this approach.
Insights
Tumor-derived organoids (tumoroids) can be established from most tumors. These micro-tumors show promise for predicting patient treatment response and guiding precision oncology decisions.
Area of Science:
- Oncology
- Biotechnology
- Genomics
Context:
- Tumor-derived organoids (tumoroids) are emerging as a powerful tool in cancer research.
- Established from diverse tumor types, these "micro-tumors" offer a patient-specific model.
- Current research focuses on optimizing culture conditions and recapitulating the tumor microenvironment.
Purpose:
- To review the potential of tumoroids in predicting patient response to cancer therapies.
- To explore the use of tumoroids in identifying molecular signatures linked to treatment efficacy.
- To assess the feasibility of integrating tumoroids into clinical decision-making for precision oncology.
Summary:
- Literature review indicates successful establishment of tumoroids from nearly all tumor types.
- Functional assays using tumoroids can predict patient treatment response and identify predictive molecular signatures.
- Despite the need for optimized culture conditions, tumoroids are increasingly applicable in treatment response prediction.
Impact:
- Tumoroids have the potential to revolutionize precision oncology by enabling personalized treatment strategies.
- Widespread clinical adoption of tumoroids could usher in a new era of cancer care.
- Ongoing global research and clinical trials are validating the clinical utility of tumoroids.
