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Updated: Aug 19, 2025

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
[Fertility preservation in transgender people]
Vincent Puy1, Fanny Magnan2, Johanna Lousqui2
1CECOS, hôpitaux universitaires Paris Seine-Saint-Denis, hôpital Jean Verdier, Bondy, France - Biologie de la reproduction, hôpitaux universitaires Paris Seine-Saint-Denis, hôpital Jean-Verdier, Bondy, France - Inserm U1016, équipe « Génomique, épigénétique et physiologie de la reproduction », Institut Cochin, université Paris Cité, Paris, France.
Abstract:
Most of transgender people plan to have a family but their fertility may be affected by gender affirmation. Hormone therapy can permanently affect gamete production, especially in trans women. Sex reassignment surgery leads to permanent sterility. In France, networks of health professionals have been organized and recommend access to fertility preservation for trans people. However, gamete collection is often difficult due to hormonal incongruence for trans women or to the invasive nature of the procedure for trans men. Future studies are required to assess the use of self-preserved gametes by trans people.
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