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Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
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One-Step Formation of Targeted Liposomes in a Versatile Microfluidic Mixing Device.

Han Shan1,2,3, Xin Sun3, Xin Liu1

  • 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China.

Small (Weinheim an Der Bergstrasse, Germany)
|November 30, 2022
PubMed
Summary
This summary is machine-generated.

A new microfluidic mixing device offers a simple, scalable method for creating targeted liposomes. This approach enables efficient molecular imaging and photothermal therapy for cancer treatment.

Keywords:
microfluidic mixingone-step formationphotoacoustic imagingphotothermal therapytargeted liposomes

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Targeted liposomes are crucial for drug delivery, molecular imaging, and cancer therapy.
  • Conventional liposome preparation methods are often complex, time-consuming, and lack reproducibility.

Purpose of the Study:

  • To develop a facile, scalable, one-step strategy for constructing targeted liposomes.
  • To engineer a microfluidic mixing device (MMD) for advanced liposome synthesis.

Main Methods:

  • A versatile microfluidic mixing device (MMD) was engineered for one-step liposome construction.
  • Programmed death-ligand 1 (PD-L1)-targeting aptamer modified indocyanine green (ICG)-liposome (Apt-ICG@Lip) was synthesized using the MMD.
  • Characterization included encapsulation efficiency and mean diameter analysis.

Main Results:

  • The MMD enabled the efficient synthesis of Apt-ICG@Lip with high encapsulation efficiency (89.9 ± 1.4%) and small mean diameter (129.16 ± 5.48 nm).
  • In vivo studies demonstrated Apt-ICG@Lip's capability for PD-L1 targeted photoacoustic imaging, fluorescence imaging, and photothermal therapy in tumor models.
  • The method proved versatile for preparing various functional targeted liposomes.

Conclusions:

  • The developed microfluidic method is concise, efficient, and scalable for producing multifunctional targeted liposomal nanoplatforms.
  • This approach offers a promising solution for molecular imaging and disease theranostics.
  • The engineered MMD provides a controllable and high-throughput platform for liposome synthesis.