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Updated: Jun 5, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
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Rapid Concentration-Dependent Liposome Size Profiling Using a Cascaded and Concentration-Encoded Microfluidic

Ruoding Diao1,2, Mingde Zheng2, Qi Sun2

  • 1Furong Laboratory, Central South University, Changsha 410008, China.

ACS Applied Materials & Interfaces
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

A new microfluidic platform enables precise control over lipid nanoparticle size, enhancing drug delivery efficiency. Optimized small nanoparticles show improved cellular uptake and tumor accumulation for better therapeutic outcomes.

Keywords:
gradient microfluidicslipid concentrationliposome sizemicrofluidic mixingtumor accumulation

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery

Background:

  • Lipid-based nanomedicines require precise size control for effective in vivo drug delivery.
  • Existing microfluidic devices struggle to comprehensively evaluate lipid concentration's impact on liposome size.

Purpose of the Study:

  • To develop a high-throughput microfluidic platform for evaluating lipid concentration effects on liposome size.
  • To accelerate the formulation development of lipid-based nanomedicines.

Main Methods:

  • Development of a cascaded and concentration-encoded microfluidic platform (CCEMP).
  • CCEMP integrates a microfluidic concentration gradient generator (MCGG) and a microfluidic liposome generator (MLG).
  • Parallel screening of six lipid concentrations with enhanced throughput.

Main Results:

  • CCEMP demonstrated 6-fold higher throughput compared to single-channel devices.
  • Optimized small liposomes showed superior cellular uptake and tumor accumulation in vitro and in vivo.
  • Drug-loaded liposomes synthesized using CCEMP exhibited enhanced delivery efficiency.

Conclusions:

  • The CCEMP offers a flexible and efficient solution for tailoring liposomal properties.
  • This platform accelerates the development of nanomedicines with improved therapeutic capacity.
  • Precise size control via CCEMP is crucial for enhancing in vivo drug delivery.