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Related Concept Videos

Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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High-Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single-Cell Level.

Mengli Zhou1,2,3, Yushu Ma1,2, Chun-Cheng Chiang1,2

  • 1UPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|November 30, 2022
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Summary

This study introduces a microfluidic platform to screen cancer cell migration inhibitors, finding many drugs don't affect fast-moving cancer cells. It identifies new drug combinations to target these resistant cells, advancing metastasis research.

Keywords:
breast cancercell migrationimage processingmetastasismicrofluidicssingle-cell analysis

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Area of Science:

  • Oncology
  • Biotechnology
  • Cell Biology

Background:

  • Cancer cell migration is crucial for metastasis and mortality.
  • Current drug discovery often overlooks migration inhibitors, focusing on cytotoxicity.
  • Standard assays mask heterogeneous cell populations driving metastasis and treatment resistance.

Purpose of the Study:

  • To develop and utilize a high-throughput microfluidic platform for individual cell migration analysis.
  • To screen compounds for their effects on cancer cell migration and growth inhibition.
  • To identify effective drug combinations targeting migratory cancer cell subpopulations.

Main Methods:

  • High-throughput microfluidic cell migration platform with robotic liquid handling and computer vision.
  • Screening of 172 compounds for migration and growth inhibition.
  • Single-cell morphological and molecular analysis to understand cell behavior.

Main Results:

  • Low correlation observed between migration inhibition and growth inhibition.
  • Many compounds inhibited bulk cell migration but spared fast-moving subpopulations.
  • Synergistic drug combinations (e.g., Bortezomib and Danirixin) identified to inhibit fast-moving cells.

Conclusions:

  • The novel platform enables rapid quantification of individual cellular motility.
  • Identified drug candidates and combinations offer new strategies for combating cancer metastasis.
  • This technology facilitates the discovery of potent migration inhibitors for cancer therapy.