Related Experiment Video
Updated: Aug 19, 2025
09:36
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
25.5K
Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases
Paola Ruffo1, Francesca De Amicis2, Emiliano Giardina3
1Medical Genetics Laboratory, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Neural Regeneration Research
|December 1, 2022
Summary
Long non-coding RNAs regulate gene expression and are implicated in neurodegenerative diseases like Alzheimer's. Their potential as diagnostic markers and therapeutic targets warrants further investigation for incurable conditions.
Area of Science:
- Molecular Biology
- Genetics
- Neuroscience
Background:
- High-throughput sequencing advances gene expression understanding.
- Epigenome and epitranscriptome editing influence mRNA function.
- Non-coding RNAs are key regulators of gene and chromosomal expression.
Purpose of the Study:
- Investigate the role of long non-coding RNAs (lncRNAs) in neurodegenerative diseases.
- Explore lncRNAs as epigenetic regulators in the central nervous system.
- Assess the diagnostic and therapeutic potential of lncRNAs for neurodegenerative disorders.
Main Methods:
- Review of current literature on lncRNAs and neurodegeneration.
- Analysis of lncRNA expression patterns in central nervous system disorders.
- Evaluation of RNA modifications and their impact on neuronal function.
Main Results:
- Long non-coding RNAs (over 200 nucleotides) function as epigenetic regulators.
- lncRNAs are abundantly expressed in the central nervous system.
- Deregulation of lncRNAs may contribute to neuronal degeneration via RNA modifications.
Conclusions:
- lncRNAs play a critical role in neurodegenerative diseases (Alzheimer's, Parkinson's, ALS, Huntington's).
- lncRNA dysregulation is linked to neuronal degeneration.
- lncRNAs hold promise for novel diagnostic and therapeutic strategies for currently incurable neurodegenerative diseases.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
01:20Types of RNA
6.0K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
6.0K
01:46Epigenetic Regulation
31.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.3K
01:37Neural Regulation
39.7K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.7K
01:53RNA Stability
33.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.8K
02:41Chromatin Structure Regulates pre-mRNA Processing
7.1K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
The chromatin structure, especially...
7.1K