Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Editing02:23

RNA Editing

9.1K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.1K
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

1.0K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.0K
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

77
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
77
CRISPR01:59

CRISPR

52.7K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
52.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry.

European heart journal·2026
Same author

Artificial intelligence-enabled electrocardiography to predict impending episodes of ventricular tachycardia in individuals under continuous heart rhythm monitoring.

The Cochrane database of systematic reviews·2026
Same author

ECG-XPLAIM: eXPlainable Locally-adaptive Artificial Intelligence Model for arrhythmia detection from large-scale electrocardiogram data.

Frontiers in cardiovascular medicine·2025
Same author

Major arrhythmias in non-dilated left ventricular cardiomyopathy: a novel prediction score.

European heart journal·2025
Same author

Commentary on ventricular arrhythmias in acute heart failure: Critical insights into the 2024 ACVC-EHRA- HFA consensus statement.

International journal of cardiology·2025
Same author

Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021.

JAMA neurology·2025

Related Experiment Video

Updated: Aug 19, 2025

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
08:05

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

2.9K

Genome Editing and Atrial Fibrillation.

Michael Spartalis1,2

  • 1Arrhythmia Unit, San Raffaele University Hospital, Milan, Italy. msparta@med.uoa.gr.

Advances in Experimental Medicine and Biology
|December 1, 2022
PubMed
Summary

Atrial fibrillation (AF) is a common heart rhythm disorder with genetic and environmental causes. This review explores genetic analysis and genome editing for AF, highlighting future research directions for patient treatment.

Keywords:
ArrhythmiaAtrial fibrillationGene therapyGeneticsGenome editing

More Related Videos

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
08:19

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping

Published on: February 22, 2018

10.0K
Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
11:33

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Published on: March 12, 2013

13.5K

Related Experiment Videos

Last Updated: Aug 19, 2025

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
08:05

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

Published on: June 29, 2022

2.9K
Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
08:19

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping

Published on: February 22, 2018

10.0K
Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
11:33

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Published on: March 12, 2013

13.5K

Area of Science:

  • Cardiology
  • Genetics
  • Molecular Biology

Background:

  • Atrial fibrillation (AF) is a prevalent arrhythmia associated with increased risks of heart failure (HF) and stroke.
  • AF pathogenesis is multifactorial, involving complex interactions between genetic predispositions and environmental factors.
  • Recent decades have witnessed significant progress in understanding the genetic underpinnings of AF.

Purpose of the Study:

  • To review current knowledge on genetic analysis and genome editing techniques applicable to atrial fibrillation.
  • To identify existing knowledge gaps and outline future research trajectories in AF genetics.
  • To explore the potential therapeutic applications of genome editing for patients diagnosed with atrial fibrillation.

Main Methods:

  • Comprehensive literature review of genetic studies in atrial fibrillation.
  • Analysis of genome editing technologies, including CRISPR-Cas9, relevant to cardiac arrhythmias.
  • Synthesis of current findings and identification of future research priorities.

Main Results:

  • Genetic factors play a significant role in the multifactorial etiology of AF.
  • Genome editing technologies offer promising avenues for precise genetic modification.
  • Gaps remain in translating genetic discoveries into clinical applications for AF management.

Conclusions:

  • Understanding the genetic basis of AF is crucial for developing targeted therapies.
  • Genome editing holds potential for correcting genetic defects contributing to AF.
  • Further research is needed to bridge the gap between genetic insights and clinical implementation of genome editing in AF treatment.