Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

563
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
563

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced invasiveness promotes the dominance of a widely-distributed carbapenem-resistant virulence-plasmid-carrying Klebsiella pneumoniae sublineage.

Nature communications·2026
Same author

Pyocyanin produced by <i>Pseudomonas aeruginosa</i> creates legacy effects that promote antibiotic resistance evolution in enterococci.

Antimicrobial agents and chemotherapy·2026
Same author

Genomic epidemiology of <i>Streptococcus pneumoniae</i> GPSC6: post-vaccine expansion of <i>β</i>-lactam-susceptible serotype 24F in Europe.

Microbial genomics·2026
Same author

CRISPR-based environmental detection of Burkholderia pseudomallei identifies sanitation gaps and melioidosis risk in northeast Thailand.

Nature communications·2026
Same author

Strain-level transmission inference across multi-kingdom metagenomic data using TRACS.

Nature microbiology·2026
Same author

Multiomics characterization of acute child illness and mortality in Africa and South Asia.

Nature communications·2026
Same journal

Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice.

Nature communications·2026
Same journal

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.

Nature communications·2026
Same journal

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity.

Nature communications·2026
Same journal

Click-polymerized polyenamine membranes for efficient lithium extraction.

Nature communications·2026
Same journal

Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.

Nature communications·2026
Same journal

Proton shuttling at electrochemical interfaces under alkaline hydrogen evolution.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Aug 19, 2025

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

11.2K

Strong pathogen competition in neonatal gut colonisation.

Tommi Mäklin1, Harry A Thorpe2, Anna K Pöntinen2,3

  • 1Helsinki Institute for Information Technology HIIT, Department of Computer Science, University of Helsinki, Helsinki, Finland. tommi.maklin@helsinki.fi.

Nature Communications
|December 1, 2022
PubMed
Summary
This summary is machine-generated.

This study reveals complex competition and synergy in neonatal gut bacteria, finding no hospital-adapted pathogen advantage. Understanding these dynamics is crucial for future therapies and preventive medicine.

More Related Videos

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

14.5K
Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

19.7K

Related Experiment Videos

Last Updated: Aug 19, 2025

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

11.2K
A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

14.5K
Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

19.7K

Area of Science:

  • Microbiome research
  • Bacterial pathogenesis
  • Genomic epidemiology

Background:

  • Gut pathogens and commensals compete, but strain-level dynamics are poorly understood.
  • Ecological factors influencing colonization potential and disease prevalence require investigation.
  • Neonatal gut microbiome development is critical for long-term health.

Purpose of the Study:

  • Quantify strain-level colonization dynamics in neonatal gut microbiomes.
  • Investigate inter- and intra-species competition and synergy.
  • Assess colonization potential of pathogens like E. coli in relation to disease.

Main Methods:

  • High-resolution metagenomics
  • Strain-level genomic epidemiology
  • Longitudinal cohort analysis of neonatal gut microbiomes

Main Results:

  • Significant inter- and intra-species competition observed.
  • Synergistic relationships identified within the Klebsiella genus.
  • No preferential colonization by hospital-adapted pathogens detected in different birth groups.
  • Strain-level colonization potential of extra-intestinal pathogenic E. coli (ExPEC) assessed.

Conclusions:

  • Gut colonization involves complex competitive and synergistic interactions.
  • Systematic surveillance of pathogens in carriage states is vital for preventive medicine.
  • Findings inform future therapeutic strategies and understanding of gut microbiome ecology.