Related Experiment Video

Updated: Aug 19, 2025

Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

19.7K

Probiotic prophylaxis to prevent ventilator-associated pneumonia in children on mechanical ventilation: A randomized

Soheil Roshanzamiri1, Maryam Alemzadeh2, Seyyedeh Narjes Ahmadizadeh2

  • 1Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Pediatrics
|December 2, 2022
PubMed

Insights

Probiotic prophylaxis significantly reduced ventilator-associated pneumonia (VAP) and diarrhea in mechanically ventilated children. This strategy offers a promising approach to prevent nosocomial infections in the Pediatric Intensive Care Unit (PICU).

Area of Science:

  • Pediatric Intensive Care
  • Infectious Disease Prevention
  • Microbiome Research

Background:

  • Ventilator-associated pneumonia (VAP) is a common nosocomial infection in Pediatric Intensive Care Units (PICUs).
  • Preventing nosocomial infections is critical to combat antibiotic resistance.
  • Probiotics are being explored as a novel strategy for infection prevention.

Purpose of the Study:

  • To investigate the efficacy of probiotic prophylaxis in preventing VAP in mechanically ventilated children.
  • To assess the impact of probiotics on reducing VAP incidence in a pediatric intensive care setting.

Main Methods:

  • A randomized, double-blind clinical trial involving 72 mechanically ventilated children (under 12 years).
  • Participants received either Limosilactobacillus reuteri DSM 17938 probiotic or a placebo twice daily.
  • VAP screening was based on clinical and laboratory evidence.

Main Results:

  • Probiotic use was associated with a significantly decreased chance of VAP (adjusted OR = 0.29; 95% CI: 0.09-0.95).
  • Probiotic recipients showed a significantly lower incidence of diarrhea compared to the placebo group (adjusted OR = 0.09; 95% CI: 0.01-0.96).

Conclusions:

  • Probiotic prophylaxis is effective in preventing VAP in mechanically ventilated children.
  • Probiotics also demonstrate efficacy in reducing diarrhea incidence in this patient population.
  • This suggests probiotics as a valuable tool for infection control in PICUs.
Abstract

Keywords:
intensive care unitsmechanical ventilationpediatricprobioticsventilator-associated pneumonia (VAP)

More Related Videos

Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay09:20

Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay

Published on: April 28, 2014

12.7K
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

11.9K

Related Concept Videos

Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.3K
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
423
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
204
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
239
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.4K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.7K