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Acute Encephalopathy in a Patient With Chronic Isotretinoin Exposure and Frequent Rizatriptan Use: A Case Report
Soheil Roshanzamiri1, Mitra Rahimi1, Shahin Shadnia1
1Toxicological Research Center, Excellence Center & Department of Clinical Toxicology, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.
Clinical Case Reports
|July 26, 2026
Summary
Prolonged isotretinoin use may be linked to acute encephalopathy, especially with concurrent rizatriptan use. This case highlights the need for careful medication review in patients experiencing neurological symptoms.
Area of Science:
- Neurology
- Pharmacology
- Toxicology
Background:
- Isotretinoin is a potent medication used for severe acne.
- Acute encephalopathy is a serious neurological condition affecting brain function.
- Drug-drug interactions are a significant concern in polypharmacy.
Purpose of the Study:
- To investigate a potential association between high-dose isotretinoin exposure, frequent rizatriptan use, and acute encephalopathy.
- To emphasize the importance of assessing undisclosed medication use in patients presenting with neurological symptoms.
Main Methods:
- Case report detailing a patient with prolonged isotretinoin exposure and frequent rizatriptan use.
- Clinical assessment and neurological evaluation of the patient.
Main Results:
- The patient developed acute encephalopathy.
- A possible association between high cumulative isotretinoin exposure, frequent daily rizatriptan use, and the neurological event was observed.
- A definitive drug-drug interaction could not be established.
Conclusions:
- High cumulative isotretinoin exposure and frequent rizatriptan use may be associated with acute encephalopathy.
- Clinicians should carefully assess medication history, including non-prescribed drugs, in patients with neurological symptoms.
- Further research is needed to confirm causality and elucidate potential mechanisms.
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