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Updated: Aug 19, 2025
An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
Published on: December 17, 2018
Covalent organic framework-loaded silver nanoparticles as robust mimetic oxidase for highly sensitive and selective
Qingqing Liu1,2, Chenchen Xu2, Su Chu2
1Huzhou Key Laboratory of Medical and Environmental Applications Technologies, School of Life Sciences, Huzhou University, Huzhou City, Zhejiang Province 313000, P. R. China. Wanghua@zjhu.edu.cn.
Abstract:
Covalent organic frameworks (COFs) were fabricated with a hierarchical flower-like hollow structure, possessing a large specific surface area, high porosity, and excellent environmental stability. In situ growth of noble silver nanoparticles (AgNPs) onto COFs was conducted yielding COF-Ag nanozymes. The structural advantages of COFs can ensure the uniform dispersion and effective size control of AgNPs. More interestingly, the oxidase-like catalytic activity of the obtained COF-Ag nanozymes could be enhanced in the presence of Hg2+ ions, which could specifically interact with AgNPs to form Ag-Hg alloys. A COF-Ag catalysis-based colorimetric platform was thereby constructed for highly selective and sensitive analysis of Hg2+ ions, showing a linear concentration range from 0.050 to 10.0 μM, with a limit of detection of about 3.7 nM. Besides, the developed colorimetric strategy was successfully applied for detecting Hg2+ ions in human blood with favorable detection recoveries, indicating its potential for applications in the biomedical analysis, environmental monitoring, and food safety fields.
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