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Updated: Aug 19, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
[Hyperpigmentation reveals Addison's disease in a pregnant woman]
Elisabeth Danielsen1, Juliana Frohnert Hansen1, Marianne Klose2
1Endokrinologisk Ambulatorium, Medicinsk Afdeling, Københavns Universitetshospital - Amager Hospital.
Abstract:
A 31-year-old woman was admitted to the local department of endocrinology for control of known anti-TPO positive hypothyroidism during pregnancy. The clinician noticed a remarkable hyperpigmentation. Primary adrenal insufficiency was diagnosed and treatment with cortico- and mineralosteroids commenced. Diagnosis of primary adrenal insufficiency during pregnancy is challenging as many symptoms overlap with normal symptoms of pregnancy. The usual diagnostic criteria cannot be used due to the altered hormone concentrations during pregnancy.
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