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Updated: Aug 19, 2025

Modeling Chemotherapy Resistant Leukemia In Vitro
Published on: February 9, 2016
Does childhood chemotherapy affect mandibular bone structures in a lifetime?
Hatice Cansu Kış1, Aykağan Coşgunarslan2, Ebru Delikan3
1Department of Orthodontics, Faculty of Dentistry, Tokat Gaziosmanpaşa University, Turkey.
Childhood chemotherapy can impact mandibular bone density, affecting cancer survivors long-term. While fractal dimension showed no significant changes, the Klemetti index revealed differences, suggesting its clinical utility for assessing bone health.
Area of Science:
- Dentistry
- Oncology
- Radiology
Background:
- Childhood cancer treatment, particularly chemotherapy, is a significant cause of bone loss in patients and survivors.
- Understanding the long-term skeletal effects of cancer therapies is crucial for patient care.
Purpose of the Study:
- To evaluate mandibular bone structures in childhood cancer survivors (CCSs) using fractal dimension (FD) analysis and the Klemetti index (KI).
- To compare these bone parameters between CCSs and a control group.
Main Methods:
- A retrospective study involving 49 CCSs and 49 cancer-free controls.
- Panoramic radiographs were analyzed using fractal dimension (FD) and Klemetti index (KI).
Main Results:
- No significant differences in mean FD values were found between CCSs and controls across analyzed regions.
- A statistically significant difference was observed in the distribution of Klemetti index (KI) categories between the groups (p = 0.015).
Conclusions:
- Childhood chemotherapy may have lasting effects on mandibular bone structure.
- The Klemetti index is a valuable clinical tool for evaluating mandibular bone health in childhood cancer survivors.
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