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Updated: Aug 19, 2025

Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
Diffuse large B-cell lymphomas, not otherwise specified, and emerging entities
Joo Y Song1, Stefan Dirnhofer2, Miguel A Piris3
1Department of Pathology, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA. josong@coh.org.
Abstract:
Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogenous group of diseases and the most common subtype of non-Hodgkin lymphoma. In the past decade, there has been an explosion in molecular profiling that has helped to identify subgroups and shared oncogenic driving mechanisms. Since the 2017 World Health Organization (WHO) classification, additional studies investigating these genomic abnormalities and phenotypic findings have been reported. Here we review these findings in DLBCL and address the proposed changes by the 2022 International Consensus Classification.
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