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D-2HG comes out of its shell: Metabolic effects on the immune environment
Juan Manuel Schvartzman1, Andrew M Intlekofer2
1Division of Hematology & Oncology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Molecular Cell
|December 2, 2022
Abstract:
A recent study by Notarangelo et al.1 highlights the potential for tumor-derived D-2HG to inhibit neighboring T cell function through a novel mechanism.
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