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Clinical trials evaluating desensitising agents. Some design and analysis issues
Robert G Newcombe1, Joon Seong2, Nicola X West1
1Cardiff University, Cardiff CF10 3AT, UK.
Introduction:
The purpose of this short communication is to draw attention to an efficient design for trials to evaluate desensitising agents, and an appropriate statistical analysis.
Methods:
Two recent sensitivity trials conducted by the Bristol Dental School Clinical Trials Group are reviewed.
Results:
The methodology used was effective to establish efficacy of the products evaluated.
Conclusions:
This methodology is recommended for wider use.
Clinical Significance:
Effective clinical trial methodology enables establishment of efficacy of desensitising products leading to patient benefit.
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