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Stroke: Molecular mechanisms and therapies: Update on recent developments
Faheem Shehjar1, Briana Maktabi1, Zainab A Rahman1
1Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, Toledo, OH, USA.
Neurochemistry International
|December 2, 2022
Summary
This study explores novel stroke treatments, including the promising drug DM199 and cell-based therapies, aiming to improve outcomes for stroke survivors. Research focuses on understanding stroke mechanisms to develop effective therapeutic strategies.
Area of Science:
- Neurology
- Pharmacology
- Regenerative Medicine
Background:
- Stroke is a leading cause of death and disability globally, with significant economic impact.
- Complex pathophysiology involves atherosclerosis, thrombus, embolus, excitotoxicity, oxidative stress, and neuroinflammation.
- Current treatments like tPA have limitations, necessitating exploration of advanced therapeutic strategies.
Purpose of the Study:
- To review current and emerging therapeutic strategies for stroke.
- To highlight the potential of DM199 and cell-based therapies in stroke treatment.
- To understand the molecular mechanisms underlying stroke for targeted drug development.
Main Methods:
- Literature review of stroke pathophysiology and therapeutic interventions.
- Analysis of emerging treatments including DM199 and various stem cell therapies.
- Discussion of molecular mechanisms and risk factors associated with stroke.
Main Results:
- DM199, a synthetic KLK1, shows potential for stroke treatment with fewer side effects than tPA.
- Cell-based therapies (Neural Stem Cells, HSCs, HUCB-MSCs) are under investigation for stroke recovery.
- Existing therapies like GABA agonists and receptor inhibitors show promise but require combination strategies.
Conclusions:
- Developing effective stroke therapies requires understanding complex molecular mechanisms and risk factors.
- DM199 and cell-based therapies represent promising avenues for improving stroke patient outcomes.
- Continued research is crucial to minimize post-stroke damage and restore neurological function.
