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Racial bias in recruitment to clinical trials on paediatric asthma

Adam Lawton1, Alexander Stephenson-Allen2, Abigail Whitehouse3

  • 1North Middlesex NHS Hospital Trust, United Kingdom.

Paediatric Respiratory Reviews
|December 2, 2022
PubMed

Insights

Clinical trials for pediatric asthma lack diversity. White children are overrepresented, while non-white children are underrepresented in asthma research, impacting treatment equity.

Area of Science:

  • Pediatric pulmonology
  • Clinical trial diversity
  • Health equity in childhood asthma

Background:

  • Asthma is the most common chronic childhood illness.
  • Disparities in medical care affect pediatric asthma outcomes.
  • Representation in clinical trials is crucial for equitable treatment.

Purpose of the Study:

  • To assess the ethnic diversity of participants in pediatric asthma clinical trials.
  • To identify the proportion of white and non-white children in asthma research over the last decade.

Main Methods:

  • Searched ClinicalTrials.gov for completed interventional pediatric asthma studies (2011-2021).
  • Analyzed demographic data for race and ethnicity of study participants.
  • Calculated the percentage of white and non-white children in the analyzed trials.

Main Results:

  • Of 112,327 patients across 208 studies, 69% were identified as White/Caucasian.
  • Fewer than 13% of participants were identified as Black/African/African-American.
  • Approximately 30% of study participants, totaling 34,207 children, were from non-white backgrounds.

Conclusions:

  • Significant underrepresentation of non-white children in pediatric asthma clinical trials was observed.
  • Researchers must prioritize representative populations in trial design.
  • Ensuring diversity in clinical trials is essential for equitable asthma treatment and outcomes.

Keywords:
AsthmaChildrenClinical trialsRacial bias

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