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Simulations of surface charge density changes during the untreated solid tumour growth
Henry Bory Prevez1, Argenis Adrian Soutelo Jimenez2, Eduardo José Roca Oria3
1Departamento de Control Automático, Facultad de Ingeniería Eléctrica, Universidad de Oriente, Santiago de Cuba, Cuba.
Royal Society Open Science
|December 5, 2022
Summary
This study models untreated tumor growth, revealing a link between surface charge density changes and tumor progression. Understanding this electrical-physiological connection can inform new cancer therapies.
Area of Science:
- Biophysics
- Cancer Research
- Mathematical Modeling
Background:
- Understanding the intrinsic behavior and kinetics of untreated solid tumors is crucial for cancer research.
- The interplay between electrical properties and physiological changes in cancer remains an area of active investigation.
Purpose of the Study:
- To develop an approximate analytical expression for simulating surface charge density changes at the tumor-host tissue interface during untreated solid tumor growth.
- To investigate the relationship between temporal changes in surface charge density and the kinetics of unperturbed solid tumor growth.
Main Methods:
- Utilized the Gompertz and Poisson equations to model tumor growth dynamics.
- Performed simulations to analyze changes in surface charge density over time.
- Correlated simulated electrical parameter changes with physiological tumor behavior.
Main Results:
- Demonstrated a close relationship between unperturbed solid tumor growth and temporal variations in surface charge density at the tumor-surrounding healthy tissue interface.
- Showed that tumor growth is governed by these dynamic changes in surface charge density.
Conclusions:
- Results support a correspondence between electrical and physiological parameters in untreated cancer, highlighting their potential role in tumor growth, progression, and immune evasion.
- Insights into surface charge density dynamics may guide the redesign of chemotherapy and immunotherapy molecules based on polarity, and inform novel therapeutic strategies.
