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Antibiotics needed to treat multidrug-resistant infections in neonates

Phoebe Cm Williams1, Shamim A Qazi2, Ramesh Agarwal3

  • 1School of Public Health, Faculty of Medicine, Edward Ford Building, The University of Sydney, Camperdown, NSW, 2006, Australia.

Bulletin of the World Health Organization
|December 5, 2022
PubMed

Insights

Neonatal infections are a major cause of death, with limited antibiotic options for drug-resistant strains. Developing a priority list for neonatal antibiotics is crucial to accelerate research and reduce infant mortality.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Neonatal infections are a primary cause of mortality globally.
  • Antimicrobial resistance (AMR) and a sparse antibiotic pipeline hinder effective neonatal treatment.
  • Few antibiotics approved for adults include neonatal dosing, highlighting a critical research gap.

Approach:

  • Review the World Health Organization (WHO) priority pathogens list for neonatal sepsis.
  • Propose a WHO multiexpert stakeholder meeting to establish a neonatal priority antibiotic development list.
  • Advocate for an international, interdisciplinary consensus to accelerate neonatal antibiotic development.

Key Points:

  • Only 4 of 40 antibiotics approved since 2000 include neonatal dosing.
  • Adult antibiotic trials significantly outnumber neonatal trials (43 vs. 6).
  • Addressing AMR in neonates requires a focused, accelerated development program.

Conclusions:

  • A dedicated neonatal antibiotic development program is essential.
  • Prioritizing specific antibiotics for neonates will streamline research efforts.
  • Reducing morbidity and mortality from multidrug-resistant infections in neonates is achievable through focused international collaboration.

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