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Risk factors associated with chronic kidney disease progression: Long-term retrospective analysis from Qatar

Ahmed Farouk Hamdi1, Ashraf Fawzy1, Essa Abuhelaiqa1

  • 1Hamad General Hospital, Hamad Medical Corporation, Qatar. Email and ORCID ID: ahamdi@hamad.qa & https://orcid.org/0000-0002-7289-4942.

Qatar Medical Journal
|December 5, 2022
PubMed

Insights

Identifying chronic kidney disease (CKD) progression factors is key. Higher HbA1c, proteinuria, and not using renin-angiotensin system blockers increase risks, alongside age, ethnicity, smoking, diabetes, and hypertension.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Public Health

Background:

  • Chronic kidney disease (CKD) progression is influenced by complex and varied risk factors.
  • Identifying these factors aids in pinpointing high-risk patients for targeted interventions.

Purpose of the Study:

  • To identify demographic and clinical risk factors associated with CKD progression and adverse patient outcomes.
  • To understand the specific risk factors within a unique population in Qatar.

Main Methods:

  • Retrospective analysis of 1020 CKD patients with complete data.
  • Follow-up conducted between January 1, 2001, and December 31, 2016.
  • Kaplan-Meier survival analysis and log-rank tests were employed.

Main Results:

  • 11.8% of patients reached end-stage kidney disease (ESKD) or death over a median of 9.3 years.
  • Risk factors for ESKD/death included higher hemoglobin A1c (diabetes), increased proteinuria, and non-use of renin-angiotensin system blockers.
  • Significant risk factors for CKD progression (eGFR decline) were older age, Arab ethnicity, smoking, diabetes mellitus, and hypertension.

Conclusions:

  • Demographic and clinical factors significantly impact CKD progression and outcomes in Qatar's population.
  • Intensifying management of modifiable risk factors may help slow CKD progression.
  • Further prospective studies are recommended to validate these findings.
Abstract

Keywords:
chronic kidney diseaseend-stage kidney diseaseprogression risk factors

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