Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

1.1K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
1.1K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

4.6K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myeloid-derived suppressor cell (MDSC)-like neutrophils induced by pulmonary infection with <i>Coccidioides posadasii</i> exacerbate disease by suppressing CD4<sup>+</sup> T cell immunity.

mBio·2026
Same author

Role of dual specificity phosphatase 1 in influencing inflammatory pathways in macrophages modulated by <i>Borrelia burgdorferi</i> lipoproteins.

Frontiers in immunology·2026
Same author

Immune-Based Prevention and Therapy Against Coccidioidomycosis: Current and Emerging Approaches.

Journal of fungi (Basel, Switzerland)·2026
Same author

Generation and Evaluation of a Multi-Epitope Vaccine Against <i>Acinetobacter baumannii</i>, a Nosocomial Bacterial Pathogen.

Vaccines·2026
Same author

Drug Discovery and Repurposing for <i>Coccidioides</i>: A Systematic Review.

Journal of fungi (Basel, Switzerland)·2025
Same author

Characterization of Pilin A and Thioredoxin A Mutant Strains of Acinetobacter baumannii, From a Transposon Insertion Library, for Pili Production and Virulence-Associated Properties.

MicrobiologyOpen·2025

Related Experiment Video

Updated: Aug 19, 2025

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux&#45;Deficient Bacterial Strain and a Single&#45;Copy Gene Expression System
05:06

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

687

Insights into Acinetobacter baumannii protective immunity.

Sean Jeffreys1, James P Chambers1, Jieh-Juen Yu1

  • 1Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, United States.

Frontiers in Immunology
|December 5, 2022
PubMed
Summary

Multi-drug resistant Acinetobacter baumannii infections are a growing threat, especially post-COVID-19. This review explores adaptive immune responses and immunotherapeutics, like vaccines and antibodies, as promising treatment strategies.

Keywords:
Acinetobacter baumanniiadaptive immunityantibody-mediated protectioncell-mediated protectionimmunotherapeuticvaccine

More Related Videos

Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System
07:59

Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System

Published on: April 25, 2025

450
Author Spotlight: A Comprehensive Protocol for Acinetobacter Biofilm Quantification, Assessment, and Visualization
07:41

Author Spotlight: A Comprehensive Protocol for Acinetobacter Biofilm Quantification, Assessment, and Visualization

Published on: August 4, 2023

3.6K

Related Experiment Videos

Last Updated: Aug 19, 2025

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux&#45;Deficient Bacterial Strain and a Single&#45;Copy Gene Expression System
05:06

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

687
Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System
07:59

Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System

Published on: April 25, 2025

450
Author Spotlight: A Comprehensive Protocol for Acinetobacter Biofilm Quantification, Assessment, and Visualization
07:41

Author Spotlight: A Comprehensive Protocol for Acinetobacter Biofilm Quantification, Assessment, and Visualization

Published on: August 4, 2023

3.6K

Area of Science:

  • Microbiology and Immunology
  • Infectious Diseases
  • Pharmacology

Background:

  • Acinetobacter baumannii is a Gram-negative bacterium causing hospital-acquired infections.
  • This pathogen exhibits extensive drug resistance, complicating treatment.
  • Acinetobacter baumannii infections pose significant mortality and economic burdens, exacerbated during the COVID-19 pandemic.

Purpose of the Study:

  • To review the adaptive immune response against Acinetobacter baumannii.
  • To highlight the role of antibody-mediated and cell-mediated protection.
  • To discuss the therapeutic applications of immunotherapies for Acinetobacter baumannii infections.

Main Methods:

  • Literature review of current knowledge on Acinetobacter baumannii immunology.
  • Analysis of adaptive immune responses, including antibody and cell-mediated immunity.
  • Evaluation of existing and potential immunotherapeutic strategies.

Main Results:

  • Adaptive immunity, particularly antibody-mediated protection, is crucial for combating Acinetobacter baumannii.
  • Advances in vaccines and monoclonal antibodies offer potential therapeutic avenues.
  • Cell-mediated immunity also plays a role in host defense against this pathogen.

Conclusions:

  • Given the rise in antimicrobial resistance, immunotherapies are vital for treating Acinetobacter baumannii infections.
  • Understanding the host adaptive immune response is key to developing effective future treatments.
  • Immunotherapeutic strategies hold significant promise for managing multi-drug resistant Acinetobacter infections.