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Related Concept Videos

Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Drug Control Governance: Regulatory Bodies and Their Impact01:03

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Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
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Drug Distribution: Overview01:11

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Drug distribution within the body is a dynamic process involving the movement of a drug in two directions across various compartments: from the bloodstream into tissues (tissue uptake) and from tissues back into the bloodstream (tissue release or redistribution). This process is passive and primarily driven by two variables: the concentration gradient between the bloodstream and the extravascular tissues and the drug's ability to cross the cell membrane.
Initially, the free drug in the...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Regulation01:25

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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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Drug Distribution: Tissue Binding01:21

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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Making drug supply chain secure traceable and efficient: a Blockchain and smart contract based implementation.

Kailash Chandra Bandhu1, Ratnesh Litoriya1, Pradeep Lowanshi1

  • 1Medi-Caps University, Indore, India.

Multimedia Tools and Applications
|December 5, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a decentralized blockchain system for healthcare supply chains, enhancing transparency and security. The solution uses Ethereum smart contracts to track pharmaceuticals, preventing fraud and ensuring data integrity.

Keywords:
BlockchainData securityFake drugsHealthcare supply chainStakeholdersTraceabilityTransparency

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Area of Science:

  • Computer Science
  • Information Systems
  • Healthcare Management

Background:

  • The healthcare supply chain is complex, facing challenges like fraud, data inaccuracy, and lack of transparency.
  • Traditional centralized systems pose risks to drug and data safety within the supply chain.
  • A decentralized track-and-trace system is crucial for improving the integrity of healthcare logistics.

Purpose of the Study:

  • To propose an end-to-end decentralized track-and-trace system for the healthcare supply chain.
  • To leverage Ethereum blockchain technology and smart contracts for enhanced data security and transparency.
  • To address the vulnerabilities of traditional supply chain models in the healthcare sector.

Main Methods:

  • Developed an Ethereum blockchain-based solution utilizing Solidity smart contracts.
  • Implemented hash functions for secure data storage on a public distributed ledger.
  • Designed decentralized application architecture and algorithms for supply chain tracking.

Main Results:

  • The proposed system effectively tracks the history of pharmaceutical goods.
  • Demonstrated average gas costs for key functionalities: overall (18,027.2), logging out (14,275), buying medicine (229,607.5), and logging (48,118.6).
  • Results were compared favorably against state-of-the-art methods, indicating system efficiency.

Conclusions:

  • The blockchain-based system enables a seamless and secure flow of medicines without intermediaries.
  • The solution enhances transparency and traceability in the pharmaceutical supply chain.
  • Presents a viable approach for building secure pharma supply chain applications using blockchain 4.0.