The MeshCODE to scale-visualising synaptic binary information

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Updated: Oct 3, 2026

Automated Quantification of Synaptic Fluorescence in C. elegans
12:22

Automated Quantification of Synaptic Fluorescence in C. elegans

Published on: August 10, 2012

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Samuel F H Barnett1, Benjamin T Goult2

  • 1Department of Cellular Biophysics, Max Planck Institute for Medical Research, Heidelberg, Germany.

Frontiers in Cellular Neuroscience
|December 5, 2022
PubMed

Keywords:
actincytoskeletondendritic spineintegrinmemorysynapsetalinvinculin

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Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.Most synapses are chemical. That means that an electrical impulse—or action potential—spurs the release of chemical messengers. These chemical messengers are also called neurotransmitters. The neuron sending the signal is called the presynaptic neuron. The neuron receiving the signal is the postsynaptic neuron.The presynaptic...
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The presynaptic neuron fires an action potential that...
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Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...