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Role of Nanozymes in Oral Cancer the Road Ahead

Dominic Augustine1, S V Sowmya1, Neethi Gujjar1

  • 1Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M.S.Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru, Karnataka 560054 India.

Topics in Catalysis
|December 5, 2022
PubMed

Insights

This review explores nanozymes, artificial enzymes with unique properties, for oral cancer diagnosis and therapy. It highlights their potential to advance oral cancer management, despite current literature gaps.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Oral cancer arises from complex interactions within the tumor microenvironment (TME), genetic changes, and risk factors like lifestyle and infections.
  • Current diagnosis and treatment of oral cancer utilize various modalities.
  • Nanozymes, or artificial enzymes, offer significant advantages over natural enzymes in biological and physical properties for tumor applications.

Purpose of the Study:

  • To review the current role and potential applications of nanozymes in oral cancer diagnosis and therapy.
  • To bridge the observed gap in literature concerning nanozymes specifically within the context of oral cancer.
  • To correlate nanozyme applications with advancements in tumor biology and biomedical research for oral cancer management.

Main Methods:

  • A comprehensive web-based literature search was conducted using Google Scholar, PubMed, and Web of Science.
  • Keywords included nanozymes, nanoparticles in cancer, oral cancer, diagnosis, therapy, TME, microbiome, molecular alterations, biosensor, targeted therapy, imaging, and tissue regeneration.
  • Studies published between 2012 and 2022, including original research, reviews, and case reports, were analyzed.

Main Results:

  • A significant lack of published literature specifically addressing nanozymes in oral cancer was identified.
  • Nanozymes demonstrate considerable potential for revolutionizing oral cancer diagnosis and therapeutics due to their unique properties.
  • The review establishes a foundational understanding of nanozyme applications in oral cancer, linking them to tumor biology and biomedical research.

Conclusions:

  • Nanozymes represent a promising frontier in the management of oral cancer, offering novel diagnostic and therapeutic strategies.
  • Further research and development of nanozymes are anticipated to significantly impact future oral cancer care.
  • This review serves as the first comprehensive assessment of nanozymes in the oral cancer field, highlighting their potential to shift paradigms in cancer treatment.
Keywords:
BiosensingCancerimagingGeneticsMicrobiomeNanoparticlesNanozymesOral cancerRegenerationTumor microenvironment

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