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Serum 25-hydroxyvitamin D3 is associated with homocysteine more than with apolipoprotein B

Nam-Kyu Kim1, Min-Ah Jung1, Beom-Hee Choi2

  • 1Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon 16499, Korea.

Nutrition Research and Practice
|December 5, 2022
PubMed

Insights

Low vitamin D levels are linked to higher homocysteine, a risk factor for cardiovascular disease. This study confirms vitamin D

Area of Science:

  • Cardiovascular Health
  • Endocrinology
  • Nutritional Science

Background:

  • Cardiovascular diseases (CVDs) represent a growing global health concern.
  • Low serum vitamin D levels are implicated in CVD risk, but underlying mechanisms require elucidation.
  • Understanding the relationship between vitamin D and CVD biomarkers is crucial for preventative strategies.

Purpose of the Study:

  • To investigate the association between serum 25-hydroxyvitamin D (25[OH]D) levels and key cardiovascular risk factors.
  • To determine the specific relationship of 25[OH]D with serum homocysteine and apolipoprotein B (ApoB).
  • To clarify the role of vitamin D in the metabolic pathways contributing to cardiovascular risk.

Main Methods:

  • Analysis of serum 25(OH)D, homocysteine, and ApoB in 518 subjects undergoing routine health examinations.
  • Application of simple, partial, and multivariate regression analyses to assess correlations.
  • Comparison of homocysteine concentrations across different tertiles of serum 25(OH)D.

Main Results:

  • Serum 25(OH)D demonstrated significant negative correlations with both homocysteine and ApoB after adjustments.
  • Multivariate analysis revealed a stronger independent association between serum 25(OH)D and homocysteine.
  • Individuals with the lowest serum 25(OH)D levels exhibited significantly higher homocysteine concentrations.

Conclusions:

  • Serum 25(OH)D concentration is more strongly associated with serum homocysteine than with ApoB.
  • This finding suggests a potential mechanistic link between vitamin D status and homocysteine metabolism in cardiovascular health.
  • Maintaining adequate vitamin D levels may be important for mitigating cardiovascular risk through homocysteine regulation.
Abstract

Keywords:
25-hydroxyvitamin D3Homocysteineapolipoprotein Bcardiovascular diseases

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